However, he was expected to make a positive impact for Mali, and he did initially, intercepting a pass before being taken down in a tough tackle.
Unfortunately, the injury appeared to be severe, and Bissouma was helped off the pitch after writhing in pain on the ground for several minutes.
The extent of the injury is still unknown, but it's a concerning development for Bissouma, who has struggled with injuries throughout his career.
His contract with Tottenham is set to expire at the end of the season, and this latest setback may further jeopardize his chances of staying with the club beyond next summer.
It's worth noting that Bissouma has been linked with a potential transfer away from Tottenham in the past, and his injury record may have contributed to the club's decision to let him go.
The midfielder was also left out of the team's Champions League squad for the league phase, which suggests that he may not have a significant role to play in the team's future plans.
As Tottenham continues to chase European football, it's likely that the club will prioritize players who can contribute to the team's success without being hindered by injuries.